Semax

Semax is a synthetic heptapeptide with the sequence Met-Glu-His-Phe-Pro-Gly-Pro, developed as an analogue of the N-terminal fragment (residues 4–10) of adrenocorticotropic hormone (ACTH). It is distinct from ACTH(4-10) itself, carrying a Pro-Gly-Pro C-terminal extension absent from the parent fragment.

The compound was developed in Russia and remains most heavily represented in Russian-language and Russian-affiliated literature — a factor that affects the breadth and accessibility of the published evidence base.