Longevity

MOTS-c

Mitochondrial-derived Peptide

Also referred to as Mitochondrial ORF of the 12S rRNA type-c.

MOTS-c is encoded within the mitochondrial genome rather than nuclear DNA. Research has focused on its role as a metabolic regulator acting through the AMPK pathway.

Published on MOTS-c

comparisonMOTS-c Peptide vs SS-31: What Does the Research Say?MOTS-c peptide is a 16-amino-acid microprotein encoded within the mitochondrial 12S ribosomal RNA, making it one of the few known peptides derived from mitochondrial rather than nuclear DNA.
Research OverviewMOTS-c Peptide: What Is It Studied For?MOTS-c is a mitochondrial-derived microprotein encoded by a short open reading frame within the 12S ribosomal RNA gene of mitochondrial DNA.