Endocrine / Reproductive

Kisspeptin

Endocrine Peptide

Also referred to as metastin, KISS1.

Kisspeptin is a neuropeptide hormone encoded by the KISS1 gene and the endogenous ligand for the G protein-coupled receptor GPR54 (also designated KISS1R). First characterised in the context of metastasis suppression, it later became a focal point in reproductive neuroendocrinology after its essential role in driving GnRH secretion from the hypothalamus was identified.

Research spans nearly two decades, with the compound studied as a master upstream regulator of the hypothalamic–pituitary–gonadal axis. The evidence base includes both preclinical mechanistic work and human studies in reproductive endocrinology.

Published on Kisspeptin

Research OverviewKisspeptin Peptide Combinations: What the Research Says About StackingKisspeptin is a neuropeptide encoded by the *KISS1* gene that functions as the primary upstream activator of the hypothalamic-pituitary-gonadal (HPG) axis.
Research OverviewKisspeptin Peptide: Mechanism of Action ExplainedKisspeptin is a neuropeptide encoded by the *KISS1* gene that functions as the primary activator of the hypothalamic-pituitary-gonadal (HPG) axis.
Research OverviewKisspeptin Peptide: What Published Research Documents Before and AfterKisspeptin is a neuropeptide encoded by the *KISS1* gene that acts as the primary endogenous ligand for the G-protein-coupled receptor KISS1R (also known as GPR54).
Research OverviewKisspeptin Peptide: Safety Profile, Side Effects, and Risks in ResearchKisspeptin is a neuropeptide encoded by the *KISS1* gene that functions as the primary upstream regulator of the hypothalamic-pituitary-gonadal (HPG) axis.
Research OverviewKisspeptin Peptide: What Is It Studied For?Kisspeptin is a neuropeptide hormone encoded by the *KISS1* gene and the endogenous ligand for the G protein-coupled receptor GPR54 (also designated KISS1R).